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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A new team has been established in a large healthcare system to conduct research. At the first meeting of the new team, the pharmacotherapy specialist was asked to submit a proposal for a randomized clinical study. What is the first step in formulating the research hypothesis for this proposal?

A) Determining a measurable outcome
B) Formulating an answerable question
C) Selecting an appropriate comparator
D) Selecting a viable intervention

2. A 53-year-old patient with an 8-year history of diabetes is currently taking glipizide 10 mg twice daily before breakfast and supper. The patient weighs 85 kg and reports a 4.5 kg weight gain in the last year. Laboratory results are:
Creatinine: 1.2 mg/dL
A1C: 8.5%
What is the most appropriate recommendation at this time for improved diabetes control?

A) Increase glipizide to 20 mg twice daily.
B) Change glipizide to metformin.
C) Change glipizide to insulin.
D) Continue with glipizide and add metformin.

3. According to the Centers for Disease Control and Prevention recommendations, administration of which vaccines must be separated by at least 4 weeks if the vaccines are not administered simultaneously?

A) Measles, mumps, and rubella (MMR), and varicella
B) Tetanus/diphtheria (Td) and hepatitis A
C) Measles, mumps, and rubella (MMR), and Haemophilus influenzae type b (Hib)
D) Tetanus/diphtheria (Td) and intranasal influenza

4. A 65-year-old woman on chronic hemodialysis presents with difficulty breathing and inability to sleep. The patient has had shortness of breath, diaphoresis, and nausea, but has not vomited.
She denies having abdominal pain, diarrhea, or chest pain. She has tachycardia and tachypnea, and exhibits peaked T waves with occasional PVCs on the ECG. Serum chemistry values are:
* Sodium: 137 mEq/L
* BUN: 125 mg/dL
* Potassium: 7.2 mEq/L
* Creatinine: 12.8 mg/dL
* Chloride: 97 mEq/L
* Glucose: 95 mg/dL
* HCO3- : 11 mEq/L
* Calcium: 8.5 mg/dL
* Albumin: 3.1 g/dL
* Phosphorus: 1.7 mg/dL
Which of the following should the pharmacotherapy specialist recommend for immediate therapy?

A) Sodium polystyrene sulfonate with sorbitol orally
B) Calcium gluconate intravenously
C) Hemodialysis
D) Sodium bicarbonate intravenously

5. From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?

A) Placebo-controlled, randomized, parallel design
B) Placebo-controlled, crossover design
C) Parallel design comparing the new therapy with the best standard therapy
D) Crossover design comparing the new therapy with the best standard therapy

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